AgPlus Diagnostics inventor, Robert Porter et al, has published a paper in the peer-reviewed Journal of Immunoassay & Immunochemistry.
The paper, ”A Novel, Generic, Electroanalytical Immunoassay Format Utilizing Silver Nano-Particles as a Bio-Label”, presents the results of the team”s evaluation of the electrochemical platform that Ag+ uses.
The silver nano-particles referred to in the paper”s title can be used as bio-labels as they can attach themselves to specific antibodies that are associated with certain health conditions. The concentration of the silver particles then corresponds to the amount of antibody present, which can be detected and measured.
The paper also describes some of the challenges that had to be overcome in developing a one step immunoassay in a point of care device. Such as identifying a suitably mild chemical that could break down silver nano-particles into the much smaller electroactive silver ions that are used for analysis, without causing any unwanted effects to the biological component of the assay platform itself.
The scientists also report that they have achieved greater electroanalytical sensitivity by breaking down a single silver nano-particle into 1 million silver ions – so there is greater amplification of the signal which can be detected and measured.